| 5. | 14.08.2021 | VfB Auerbach 1906 (H) | 5:0 | - | x | - | |
| 7. | 21.08.2021 | FSV Union Fürstenwalde (H) | 6:1 | - | x | - | |
| 8. | 29.08.2021 | Berliner AK 07 (A) | 0:3 | 1 | x | - | |
| 9. | 01.09.2021 | VSG Altglienicke (H) | 0:3 | - | - | x | |
| 3. | 04.09.2021 | Ludwigsfelder FC (A) | 0:2 | 1 | - | - | |
| 12. | 25.09.2021 | FC Eilenburg (H) | 9:0 | 3 | - | - | |
| 13. | 01.10.2021 | VfB Germania Halberstadt (A) | 0:0 | - | - | - | |
| 6. | 06.10.2021 | Tennis Borussia Berlin (A) | 2:2 | - | - | x | |
| 4. | 09.10.2021 | FSV Optik Rathenow (A) | 3:4 n.V. | - | - | x | |
| 14. | 16.10.2021 | ZFC Meuselwitz (H) | 3:0 | - | - | - | |
| 11. | 20.10.2021 | Chemnitzer FC (A) | 1:1 | - | - | x | |
| 15. | 24.10.2021 | SV Tasmania Berlin (A) | 2:1 | - | x | - | |
| 4. | 27.10.2021 | FC Carl Zeiss Jena (A) | 0:1 | - | - | x | |
| 16. | 31.10.2021 | SV Babelsberg 03 (H) | 2:0 | - | - | x | |
| 10. | 10.11.2021 | 1. FC Lokomotive Leipzig (A) | 1:3 | 1 | - | x | |
| 18. | 20.11.2021 | Hertha BSC II (H) | 2:2 | - | - | - | |
| 17. | 24.11.2021 | SV Lichtenberg 47 (A) | 0:4 | 1 | - | x | |
| 19. | 27.11.2021 | BSG Chemie Leipzig (A) | 1:2 | - | - | - | |
| 20. | 05.12.2021 | FSV 63 Luckenwalde (A) | 2:3 | - | - | x | |
| 21. | 10.12.2021 | BFC Dynamo (H) | 1:1 | - | - | - | |
| 0. | 12.01.2022 | SV Wacker 09 Cottbus-Ströbitz (H) | 6:0 | - | - | - | |
| 0. | 21.01.2022 | Hertha BSC II (H) | 2:1 | - | - | x | |
| 23. | 29.01.2022 | FC Carl Zeiss Jena (H) | 0:1 | - | - | - | |
| 24. | 05.02.2022 | VfB Auerbach 1906 (A) | 0:2 | - | - | x | |
| 28. | 06.03.2022 | VSG Altglienicke (A) | 3:0 | - | x | - | |
| 30. | 20.03.2022 | Chemnitzer FC (H) | 0:1 | - | - | - | |
| 6. | 26.03.2022 | SV Babelsberg 03 (H) | 2:0 | 1 | - | x | |
| 25. | 30.03.2022 | Tennis Borussia Berlin (H) | 2:2 | - | - | x | |
| 31. | 03.04.2022 | FC Eilenburg (A) | 1:1 | - | - | x | |
| 32. | 06.04.2022 | VfB Germania Halberstadt (H) | 3:1 | 2 | - | x | |
| 33. | 10.04.2022 | ZFC Meuselwitz (A) | 1:4 | - | - | - | |
| 34. | 14.04.2022 | SV Tasmania Berlin (H) | 5:0 | - | - | - | |
| 29. | 19.04.2022 | 1. FC Lokomotive Leipzig (H) | 1:1 | - | - | - | |
| 35. | 23.04.2022 | SV Babelsberg 03 (A) | 0:2 | - | - | x | |
| 36. | 01.05.2022 | SV Lichtenberg 47 (H) | 4:1 | 1 | - | - | |
| 37. | 08.05.2022 | Hertha BSC II (A) | 1:1 | - | - | - | |
| 38. | 15.05.2022 | BSG Chemie Leipzig (H) | 4:1 | - | - | - | |
| 7. | 21.05.2022 | VfB 1921 Krieschow (N) | 0:2 | - | - | - | |
