| 8. | 29.08.2021 | Berliner AK 07 (A) | 0:3 | - | x | - | |
| 9. | 01.09.2021 | VSG Altglienicke (H) | 0:3 | - | x | - | |
| 3. | 04.09.2021 | Ludwigsfelder FC (A) | 0:2 | - | - | x | |
| 12. | 25.09.2021 | FC Eilenburg (H) | 9:0 | - | - | - | |
| 13. | 01.10.2021 | VfB Germania Halberstadt (A) | 0:0 | - | - | x | |
| 6. | 06.10.2021 | Tennis Borussia Berlin (A) | 2:2 | - | x | - | |
| 4. | 09.10.2021 | FSV Optik Rathenow (A) | 3:4 n.V. | - | x | - | |
| 14. | 16.10.2021 | ZFC Meuselwitz (H) | 3:0 | - | - | x | |
| 11. | 20.10.2021 | Chemnitzer FC (A) | 1:1 | - | - | x | |
| 15. | 24.10.2021 | SV Tasmania Berlin (A) | 2:1 | - | - | x | |
| 4. | 27.10.2021 | FC Carl Zeiss Jena (A) | 0:1 | - | x | - | |
| 16. | 31.10.2021 | SV Babelsberg 03 (H) | 2:0 | - | x | - | |
| 10. | 10.11.2021 | 1. FC Lokomotive Leipzig (A) | 1:3 | - | x | - | |
| 5. | 13.11.2021 | Fortuna Babelsberg (H) | 8:0 | 1 | - | - | |
| 18. | 20.11.2021 | Hertha BSC II (H) | 2:2 | - | x | - | |
| 17. | 24.11.2021 | SV Lichtenberg 47 (A) | 0:4 | - | x | - | |
| 19. | 27.11.2021 | BSG Chemie Leipzig (A) | 1:2 | - | x | - | |
| 20. | 05.12.2021 | FSV 63 Luckenwalde (A) | 2:3 | - | - | x | |
| 21. | 10.12.2021 | BFC Dynamo (H) | 1:1 | - | - | x | |
| 22. | 18.12.2021 | FSV Optik Rathenow (A) | 0:2 | - | - | - | |
| 0. | 12.01.2022 | SV Wacker 09 Cottbus-Ströbitz (H) | 6:0 | - | - | - | |
| 0. | 21.01.2022 | Hertha BSC II (H) | 2:1 | - | - | x | |
| 23. | 29.01.2022 | FC Carl Zeiss Jena (H) | 0:1 | - | - | x | |
| 24. | 05.02.2022 | VfB Auerbach 1906 (A) | 0:2 | - | - | x | |
